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26 Eylül 2018 tarihinde eklendi, 8 kez okundu.

Ethionamide should not be used in children less than 12 years of age , infants, or neonates unless the organisms are definitely resistant to primary therapy and systemic disease dissemination or life-threatening tuberculosis complications is imminent.

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Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication may develop serious side effectsbut with frequent visits to your doctorthis risk can be minimized.

Ethionamide may be bacteriostatic or bactericidal in actiondepending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organismEthionamidelike prothionamide and pyrazinamideis a nicotinic acid derivative related to isoniazidIt is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazidIsoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.

Ethinamate is bacteriostatic against MtuberculosisIn a study examining ethionamide resistanceethionamide administered orally initially decreased the number of culturable Mycobacterium tuberculosis organisms from the lungs of H37Rv infected miceDrug resistance developed with continued ethionamide monotherapybut did not occur when mice received ethionamide in combination with streptomycin or isoniazid.

Tell your doctor right away if any of these unlikely but serious side effects occurunusual hungerunusual sweatingshakinesspersistent nausea/vomitingunusual tiredness/weaknessyellowing eyes/skindark urinejoint pain/swellingslow heartbeatmental/mood changessuch as nervousnessrestlessnessdepression

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