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Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic dosesespecially in combination with other drugs known to cause this effectPatients with impaired renal function and elderly patientseven those with normal renal and hepatic functionare at increased riskOnce colchicine treatment is ceasedthe symptoms generally resolve within 1 week to several months.
Co-administration of colchicine capsules with propafenonea P-gp inhibitorat 225 mg BID for 5 daysin a pharmacokinetic study in healthy volunteersdid not cause any changes in systemic levels of colchicineThis indicates that propafenone can be administered with colchicine capsules without any dose adjustmentHoweverthese results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P-gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
Gout is rare in pediatric patientsthe safety and effectiveness of colchicine capsules in pediatric patients has not been evaluated in controlled studies.
Taking certain medicines with colchicine capsules can cause your level of colchicine to be too highespecially if you have kidney or liver problemsTell your healthcare provider about all your medical conditionsincluding if you have kidney or liver problemsYour dose of colchicine capsules may need to be changedEven medicines that you take for a short period of timesuch as antibioticscan interact with colchicine capsules and cause serious side effects or death.
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