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Table 3Adverse Reactions in Pooled Placebo-ControlledAdd-On Studies in Adults Experiencing Partial Onset Seizures.

Pre-marketing data from clinical studies conducted in adults indicate that levetiracetam did not influence the serum concentrations of existing antiepileptic medicinal productsphenytoincarbamazepinevalproic acidphenobarbitallamotriginegabapentin and primidoneand that these antiepileptic medicinal products did not influence the pharmacokinetics of levetiracetam.

The following adverse reactions have been reported in patients receiving marketed KEPPRA worldwideThe listing is alphabetizedabnormal liver function testacute kidney injuryanaphylaxisangioedemaagranulocytosischoreoathetosisdrug reaction with eosinophilia and systemic symptomsDRESSdyskinesiaerythema multiformehepatic failurehepatitishyponatremiamuscular weaknesspancreatitispancytopeniawith bone marrow suppression identified in some of these casespanic attackthrombocytopeniaand weight lossAlopecia has been reported with KEPPRA userecovery was observed in majority of cases where KEPPRA was discontinued.

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