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Undesirable alterations in lipids have been observed in patients treated with atypical antipsychoticsincluding ClozarilClinical monitoringincluding baseline and periodic follow-up lipid evaluations in patients using clozapineis recommended.
Clozaril must be dispensed under strict medical supervision in accordance with official recommendationssee section 4.4
It is important to begin taking this drug at a low doseincreasing your dose slowlyto lessen side effects such as dizzinessdrowsiness and seizuresFollow your doctor’s instructions exactlyYour dosage is based on your medical condition and response to therapySince clozapine can cause a decrease in white blood cellsyou will need to get blood tests done regularly as directedBe sure to keep all appointments for these laboratory testsSee also Notes section
Clozaril is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severeuntreatable neurological adverse reactions to other antipsychotic agentsincluding atypical antipsychotics.
Clozaril is not approved for the treatment of dementia-related behavioural disturbances.
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the effectiveness of clozaril in reducing the risk of recurrent suicidal behavior was assessed in the international suicide prevention trial intersept , a trademark of novartis pharmaceuticals corporation .