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75 mg PO qDay without a loading doserecommended as alternative to aspirin or concomitantly with aspirin if patient not at increased risk for bleeding but at high risk for cardiovascular disease.
Clopidogrel is metabolized to its active metabolite in part by CYP2C19Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibitionsee WARNINGS AND PRECAUTIONS
AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.
Blood and lymphatic system disordersAgranulocytosisaplastic anemia/pancytopeniathrombotic thrombocytopenic purpuraTTPacquiredhemophilia A Gastrointestinal disordersColitisincluding ulcerative or lymphocytic colitispancreatitisstomatitisgastric/duodenal ulcerdiarrhea General disorders and administration site conditionFever Hepatobiliary disordersAcute liver failurehepatitisnoninfectiousabnormal liver function test Immune system disordersHypersensitivity reactionsanaphylactoid reactionsserum sickness Musculoskeletalconnective tissue and bone disordersMyalgiaarthralgiaarthritis Nervous system disordersTaste disordersheadacheageusia Psychiatric disordersConfusionhallucinations Respiratorythoracic and mediastinal disordersBronchospasminterstitial pneumonitiseosinophilic pneumonia Renal and urinary disordersIncreased creatinine levels Skin and subcutaneous tissue disordersMaculopapularerythematous or exfoliative rashurticariabullousdermatitiseczematoxic epidermal necrolysisStevens-Johnson syndromeacute generalized exanthematous pustulosisAGEPangioedemadrug-induced hypersensitivity syndromedrug rash with eosinophilia and systemic symptomsDRESSerythema multiformelichen planusgeneralized pruritus Vascular disordersVasculitishypotension.
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