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Combivent can produce paradoxical bronchospasm that can be life-threatening.

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Additional side effects identified from the published literature and/or post-marketing surveillance on the use of ipratropium bromide-containing productssingly or in combination with albuterolincludehypersensitivitypharyngeal edemamouth edemaurinary retentionmydriasisbronchospasmincluding paradoxical bronchospasmcases of precipitation or worsening of narrow-angle glaucomaglaucomaintraocular pressure increasedacute eye painhalo visionblurred visionaccommodation disorderocular irritationcorneal edemaconjunctival hyperaemianasal congestiondrying of secretionsmucosal ulcersstomatitisirritation from aerosolthroat irritationdry throatwheezingexacerbation of COPD symptomshoarsenesspalpitationsheartburndrowsinessCNS stimulationcoordination difficultyflushingalopeciahypotensionedemagastrointestinal distressdiarrheanauseavomitinggastrointestinal motility disorderconstipationhypokalemiamental disorderhyperhidrosismuscle spasmsmuscular weaknessmyalgiaastheniamyocardial ischemiadiastolic blood pressure decreasedand systolic blood pressure increased.

Along with its needed effectsalbuterol/ipratropium may cause some unwanted effectsAlthough not all of these side effects may occurif they do occur they may need medical attention.

Patients should be cautioned to avoid spraying the aerosol into their eyes and be advised that this may result in precipitation or worsening of narrow-angle glaucomamydriasisincreased intraocular pressureacute eye pain or discomforttemporary blurring of visionvisual halos or colored images in association with red eyes from conjunctival and corneal congestionPatients should also be advised that should any combination of these symptoms developthey should consult their physician immediately.

Because of the potential for tumorigenicity shown for albuterol in animal studiesa decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.

COMBIVENT Inhalation Aerosol is indicated for use in patients with chronic obstructive pulmonary diseaseCOPDon a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator.

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in addition to the adverse reactions reported in thecontrolled clinical trial with combivent respimat, adverse reactioninformation concerning cfc-propelled combivent inhalation aerosolis derived from two 12-week controlled clinical trials n 358 forcfc-propelled combivent inhalation aerosol .



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